ZEN Graphene Solutions has announced that it has developed a potential graphene-based antibiotic, antiviral and antifungal compound.
Recent testing results from the University Health Network/Mount Sinai Hospital Department of Microbiology in Toronto are said to indicate that this patent pending formulation could be a medical breakthrough in the treatment of numerous human-contracted pathogens including upper and lower respiratory tract infections - where COVID-19 is a major contributor - as well as drug resistant organisms.
Greg Fenton, CEO commented, "This broad-spectrum compound is a novel solution that could have an impact on infectious disease management. It has the potential to act as a targeted treatment for multi-drug resistant organisms (MDR) as well. As in previously released results on the effectiveness of a similar compound against COVID-19, this graphene-based treatment could be against viral infections. We will be exploring its use not only in the fight against the current global pandemic, but also against numerous other pathogens... Based on this breakthrough and an urgent need for such treatments, we will seek immediate collaborations with potential pharmaceutical partners to optimize the delivery mechanisms to target infections in general and especially those common in the respiratory tract."
Among the reported results of the graphene compound were a 99.9% effeciency against both gram-positive and gram-negative aerobic bacteria, 99.9% effeciency against Candida Albicans (fungus/yeast), extremely low Minimum Inhibitory Concentrations (MIC) leading to the potential use in humans, and more.
ZEN has filed a provisional patent on these graphene compounds, and noted that additional testing will be required to determine the full spectrum of activity against other pathogens. Cytotoxicity studies are currently underway.
Dr. Tony Mazzulli, who conducted the testing, commented, "This Graphene Compound (GC) appears to be active against both gram positive (e.g. Streptococci and Staphylococci) and gram negative (e.g. E. coli, H. influenzae, M. catarrhalis) bacteria as well as common yeast (e.g. Candida albicans) at extremely low concentrations. These results are promising. Additional testing against a broader range of bacterial species is required to determine the full spectrum of activity of this GC."
Dr. Mazzulli added, "The relatively low concentrations of GC required to achieve an antimicrobial effect is also promising. Although one cannot directly compare the MICs of different compounds to determine their relative efficacy, the extremely low concentrations of this GC show an effect well below the concentration required of commonly used antibiotics to show a similar effect. These concentrations are also in keeping with concentrations that have been shown to have an antiviral effect of this GC as well."
Dr. Mazzulli concluded his report by stating, "In the clinical setting, if GC can be shown to be safe and effective, it could provide a breakthrough alternative therapy with potentially significant impact on the practice of family medicine (who initially see most of these common infections) but also in the fields of Otolaryngology, Ophthalmology, and even in the Intensive Care Unit where MDR organisms are a major challenge for treatment."
The company will be following up on recommendations from Dr. Mazzulli and further testing this provisional patent pending graphene compound for a full spectrum analysis of its biocidal activity. The company is also focused on building a team to support this new potential pharmaceutical agent.
It was stated that Zen is not making any express or implied claims that its product has the ability to eliminate, cure or contain the COVID-19 (or SARS-2 Coronavirus) at this time, it must receive Health Canada or FDA approvals for any of the products or solutions discussed.