Researchers in China and Japan have developed a graphene oxide based fluorescence assay for fast, ultra-sensitive, and selective detection of protein and demonstrated its use for detection of a prognostic indicator in early-stage cancer, cyclin A2.

Although the researchers have managed to detect cyclin A2 in their lab set-up with high sensitivity and specificity, this method still can not be applied to detect cyclin A2 in clinical samples due to the trace amount of cyclin A2 in the cell total protein. The team is trying to incorporate a signal amplification step to increase the output signal and detection sensitivity to solve this issue.