Researchers in India and Japan have developed an improved method for using graphene-based transistors to detect disease-causing genes.
The team improved sensors that can detect genes through DNA hybridization, which occurs when a 'probe DNA' combines with its complementary 'target DNA.' Electrical conduction changes in the transistor when hybridization occurs. The improvement was done by attaching the probe DNA to the transistor through a drying process. This eliminated the need for a costly and time-consuming addition of 'linker' nucleotide sequences, which have been commonly used to attach probes to transistors.