In past years we've seen many research papers describing how graphene could be used for DNA sequencing (see for example here and here). Now researchers from Seoul National University are suggesting a new method to reduce 1/f noise in graphene based sequencing devices. First, they replace the silicon substrate that is usually used with a quartz-based substrate. Second, they use few-layer graphene instead of single or bilayer graphene.

The quartz substrate results in almost six times lower noise - because the silicon creates most of the 1/f noise. Using few-layer graphene instead of single-layer or dielectric layer coated graphene also simplifies the fabrication steps and allows for identical pore size during the pore drilling.